Stimu-Max - oral therapy for capable to become
straight dysfunctions. Perfect competitive inhibitor of cyclic guanosine of
monophosphate (cGMP) is defined phosphodiesterase type 5 (PDE5).
The physiological mechanism of installation of the
member involves release of a nitric oxide in the cavernosum case during sexual
stimulation. The nitric oxide then activates guanylate enzyme циклаза; which leads to increased cGMP to levels, making a
relaxation of smooth muscles in the cavernosumcase and allowing blood inflow. Sildenafil
has no direct laxative effect on the isolated human cavernosum case, but it
increases effect of a nitric oxide, suppressing phosphodiesterase type 5 (PDE5)
which is responsible for cGMP degradation in the cavernosum case. When sexual
stimulation causes local release of a nitric oxide, PDE5 prohibition by
Sildenafil reasons the increased levels of cGMP in the cavernosum case, leading
to a relaxation of smooth muscles and blood inflow to the cavernosum case.Sildenafil
in recommended doses has no effect for lack of sexual stimulation.Stimu-Max is
quickly absorbed with absolute bioaccumulation about 40 %. Its pharmacokinetics
is proportional to a dose on a recommended range of a dose.
It’s eliminated predominantly by a hepatic metabolism
also it is transformed to an active metabolite with the properties similar to
parent Sildenefil. At and Sildenafil and a metabolite there is a limiting half
of life about 4 hours.For Sildenafil serve as contra-indication with organic
nitrates as it can potentiate their hypotensive effects.
Caution is required in patients with hepatic or
nephritic deterioration. The preparation shouldn't be used in patients with
preliminary transition from cardiovascular diseases as there is a potential for
warm risk of sexual activity. The preparation should be distributed by only the
medical instruction and under strict medical supervision.
For the majority of patients the recommended dose
makes 50 mg taken as necessary approximately for 1 hour before sexual activity.
Based on efficiency and tolerance, the dose can be increased to the maximum
recommended dose of 100 mg or is reduced to 25 mg. The maximum, recommended to
dose out frequency, once in day.
The accompanying government of Sildenafil with drugs
which forbids cytochrome isoenzyme as to Cimentidine, Eritomitsin,
Itraconazole, Ketokonazol and inhibitors of a protease of HIV, can reduce
permission of Sildenafil to which, probably, needs reduction of its dose. Stim-Max
was well allowed with recommended doses. Diarrhea, headache, washing off,
dizziness, visual disorders, nasal congestion or priapism are
rare, but are sometimes reported.
